Petsmile is made in the USA with human-grade ingredients. It contains calcium, magnesium, phosphates, to re-mineralize enamel. Petsmile is BPA-free, silica-free, sulfate-free, paraben-free, gluten-free, allergy-free, and vegan. Did you know brushing your pet’s teeth daily with Petsmile Professional Toothpaste will help them live happier, healthier, longer lives? Just like you, cats and dogs also get cavities, lose teeth, experience receding gums, and get periodontal diseases such as gingivitis. Using Petsmile daily will significantly improve the oral health of your dog or cat. It’s been proven that good oral health will help prevent heart, liver, and kidney diseases. The no-fuss no brush formula makes it easy to improve and maintain even the fussiest pet’s oral health. Simply apply Petsmile on your cat or dog’s teeth and let their tongue do the rest. Your pet can immediately eat or drink after applying Petsmile, no need to wait. However, for best results, we recommend brushing your pet’s teeth with our Petsmile Professional Pet Toothbrush - Patented 45° Dual-Ended Brush Head once or twice a day to better remove debris, plaque, and massage gums for improved blood flow.